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Severity of Airway Obstruction May Not Correlate With Weight Gain or Failure to Thrive in Infants With Robin

Esperanza Mantilla-Rivas1, Michael K Boyajian1, Md Sohel Rana2

  • 1Division of Plastic and Reconstructive Surgery, Children's National Hospital.

The Journal of Craniofacial Surgery
|March 26, 2021
PubMed

Insights

This study found no significant link between airway obstruction severity and poor weight gain in infants with Robin sequence (RS). Further research is needed to understand these complex patient needs.

Area of Science:

  • Pediatric Pulmonology
  • Genetics and Rare Diseases
  • Neonatology

Background:

  • Robin sequence (RS) infants often exhibit upper airway obstruction and feeding difficulties.
  • Failure to thrive (FTT) is a common concern in RS, potentially linked to respiratory issues.
  • The relationship between airway obstruction severity and FTT in RS has not been extensively studied.

Purpose of the Study:

  • To investigate the correlation between polysomnographic (PSG) findings and weight gain in infants with RS.
  • To explore the association between PSG parameters, calorie intake, and FTT in RS patients.

Main Methods:

  • A prospective review of PSG data and serial weight measurements in infants with RS.
  • Logistic regression analysis to assess the association between PSG variables, calorie intake, and FTT.
  • Poisson and linear regression to analyze categorical PSG variables and weight gain correlation.

Main Results:

  • No significant association was found between the apnea-hypopnea index, oxygen saturation nadir, or time with O2 saturation below 90% and FTT in RS patients.
  • Maximum end-tidal carbon dioxide and average calorie intake also did not show a significant association with FTT.
  • No significant correlations were identified between PSG parameters and the percentage of weight gain.

Conclusions:

  • This pilot study challenges the assumption that upper airway obstruction severity directly correlates with poor weight gain or FTT in RS.
  • Larger prospective studies are recommended to validate these findings.
  • Individualized treatment approaches are crucial for managing RS patients.
Abstract

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