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Coronary CT Angiography-derived Fractional Flow Reserve Testing in Patients with Stable Coronary Artery Disease:
Bjarne L Nørgaard1, Timothy A Fairbairn1, Robert D Safian1
1Department of Cardiology, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, 8200 Aarhus, Denmark (B.L.N., J.M.J.); Liverpool Centre for Cardiovascular Science, Liverpool Heart and Chest Hospital, Liverpool, England (T.A.F.); Department of Cardiology and Radiology, Beaumont Health System, Royal Oak, Mich (R.D.S., K.M.C., G.R.); Division of Cardiology, Loyola University Chicago, Chicago, Ill (M.G.R.); Monash Cardiovascular Research Centre, Monash University, Monash University and MonashHeart, Monash Health, Clayton, Victoria, Australia (B.K.); Department of Cardiology, Stanford University School of Medicine, Palo Alto, Calif (K.N.); Department of Cardiology, Hospital of Southwest DK, Esbjerg, Denmark (N.P.S.); Department of Cardiovascular Medicine, Gifu Heart Center, Gifu, Japan (H.M.); and Department of Medical Imaging, St Paul's Hospital, Vancouver, Canada (J.L.).
Insights
Noninvasive fractional flow reserve derived from coronary CT angiography (FFRCT) offers clinical benefits for coronary artery disease. Standardized interpretation and reporting are crucial for its integration into clinical practice and future research.
Area of Science:
- Cardiovascular Imaging
- Interventional Cardiology
- Medical Device Technology
Background:
- Noninvasive fractional flow reserve derived from coronary CT angiography (FFRCT) is gaining traction for managing coronary artery disease.
- Evidence supports FFRCT's clinical utility in moderate coronary disease, but interpretation and reporting standards are underdeveloped.
- FFRCT provides comprehensive coronary tree data, necessitating standardized analysis guidelines for clinical adoption and research.
Purpose of the Study:
- To establish expert recommendations for standardized interpretation and reporting of FFRCT analysis.
- To facilitate the integration of FFRCT into routine clinical practice.
- To guide future research involving FFRCT.
Main Methods:
- This report compiles expert opinion and recommendations.
- Focuses on a standardized approach to FFRCT interpretation and reporting.
- Addresses the integration of FFRCT results into clinical workflows.
Main Results:
- FFRCT analysis yields extensive pressure and flow data across the coronary tree.
- Standardized interpretation and reporting are essential for consistent clinical application.
- Expert consensus provides a framework for consistent FFRCT evaluation.
Conclusions:
- Standardized interpretation and reporting of FFRCT are vital for its widespread clinical adoption.
- Consistent FFRCT analysis will enhance its utility in patient management and research.
- This expert opinion offers a foundational approach to FFRCT reporting.
Abstract:
Noninvasive fractional flow reserve derived from coronary CT angiography (FFRCT) is increasingly used in patients with coronary artery disease as a gatekeeper to the catheterization laboratory. While there is emerging evidence of the clinical benefit of FFRCT in patients with moderate coronary disease as determined with coronary CT angiography, there has been less focus on interpretation, reporting, and integration of FFRCT results into routine clinical practice. Because FFRCT analysis provides a plethora of information regarding pressure and flow across the entire coronary tree, standardized criteria on interpretation and reporting of the FFRCT analysis result are of crucial importance both in context of the clinical adoption and in future research. This report represents expert opinion and recommendation on a standardized FFRCT interpretation and reporting approach. Published under a CC BY 4.0 license.
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