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Updated: Nov 11, 2025

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Published on: April 4, 2025
End-stage kidney disease: The last 12 months.
Sarah So1, Frank P Brennan2, Kelly Chenlei Li3
1MBBS, FRACP, Nephrologist and Advanced Trainee in Palliative Medicine, St George Hospital, Sydney, NSW.
Dialysis may not benefit all patients with end-stage kidney disease (ESKD), especially older individuals with other health issues. Early general practitioner (GP) involvement in conservative management and renal supportive care is recommended for better patient outcomes.
Area of Science:
- Nephrology
- Geriatric Medicine
- Palliative Care
Background:
- Chronic kidney disease (CKD) prevalence is rising in Australia's aging population.
- Dialysis offers limited survival benefits for elderly patients with significant comorbidities and poor functional status.
- Conservative management and renal supportive care are emerging alternatives to dialysis.
Purpose of the Study:
- To outline key aspects of end-stage kidney disease (ESKD) care.
- To highlight the evolving understanding of treatment benefits in advanced kidney disease.
- To emphasize the role of general practitioners (GPs) in managing ESKD.
Main Methods:
- Review of current literature and clinical practices in nephrology and palliative care.
- Discussion of patient-centered approaches in ESKD management.
- Analysis of the trajectory of CKD and ESKD.
Main Results:
- Conservative management may be more beneficial than dialysis for select ESKD patients.
- Renal supportive care integrates palliative principles into nephrology.
- Early GP involvement is crucial throughout the CKD and ESKD patient journey.
Conclusions:
- Care for patients with ESKD requires a multidisciplinary approach.
- Prognostication and advance care planning are essential components of ESKD management.
- Integrating palliative care principles improves quality of life for patients with advanced kidney disease.
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