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Case report: restored vision after ocular Closantel intoxication and blindness
Mohammad Reza Khalili1, Athar Zareei2
1Poostchi Ophthalmology Research Center, Shiraz University of Medical Sciences, Zand Street, Shiraz, Iran.
BMC Ophthalmology
|April 1, 2021
Summary
Closantel intoxication can cause temporary blindness, but prompt medical attention and treatment may lead to full vision recovery. This case highlights the potential reversibility of ocular toxicity from accidental Closantel ingestion.
Area of Science:
- Veterinary medicine
- Ophthalmology
- Toxicology
Background:
- Closantel, an anti-parasitic drug for veterinary use, is contraindicated in humans.
- Accidental Closantel ingestion in humans can lead to severe ocular toxicity.
- This report details the first documented case of complete visual function restoration after Closantel intoxication.
Observation:
- A 47-year-old man ingested approximately 20 cc of 5% Closantel (15.87 mg/kg).
- The patient experienced progressive vision loss, reaching hand motion (HM) visual acuity by day 14.
- Electroretinography (ERG) revealed a significant reduction in b-wave amplitude under both photopic and scotopic conditions.
Findings:
- Despite initial severe vision impairment, the patient's visual acuity unexpectedly improved.
- Full visual acuity was restored by day 28 post-ingestion.
- Follow-up at 3 years showed normal visual acuity (20/20) and normal ERG findings, indicating complete recovery.
Implications:
- Immediate medical referral and management are crucial for Closantel intoxication to prevent long-term visual impairment.
- The case suggests a potential dose-response relationship and reversibility of Closantel-induced ocular toxicity.
- Early intervention may lead to complete resolution of visual and electrophysiological abnormalities.
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