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Published on: June 21, 2017
Regioselective Three-Component Synthesis of Vicinal Diamines via 1,2-Diamination of Styrenes
Jie Cao1,2, Daqi Lv1,2, Fei Yu2
1College of Chemistry, Fuzhou University, 2 Xueyuan Road, Fuzhou, Fujian 350108, P. R. China.
Abstract:
The vicinal diamine motif plays a significant role in natural products, drug design, and organic synthesis, and development of synthetic methods for the synthesis of diamines is a long-standing interest. Herein, we report a regioselective intermolecular three-component vicinal diamination of styrenes with acetonitrile and azodicarboxylates. The diamination products can be produced in moderate to excellent yields via the Ritter reaction. Synthetic applications and theoretical studies of this reaction have been conducted.
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