Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Modern Molecular Taxonomy01:29

Modern Molecular Taxonomy

344
Advancements in molecular biology have revolutionized the identification and characterization of bacteria, with multiple methods leveraging DNA sequencing for enhanced precision. As sequencing technologies improve and costs decline, these approaches are increasingly used in clinical, environmental, and evolutionary studies.Multilocus Sequence Typing (MLST) examines several housekeeping genes, essential chromosomal genes encoding cellular functions, to distinguish strains. Approximately...
344
Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

6.5K
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
6.5K
Southern Blot02:57

Southern Blot

21.3K
Agarose gel electrophoresis is very useful in separating DNA fragments by size. Running a DNA ladder containing fragments of the known length alongside the sample helps determine the approximate length of the sample DNA fragments. However, additional steps are needed to verify the sequence identity of the sample DNA fragments.
Denatured DNA fragments must be transferred onto a carrier membrane from the gel to make it accessible to a probe - a small ssDNA fragment complementary to the target DNA...
21.3K
Sanger Sequencing01:57

Sanger Sequencing

765.2K
DNA sequencing is a fundamental technique that is routinely used in the biological sciences. This method can be applied to a range of questions at different scales - from the sequencing of a cloned DNA fragment or the study of a mutation in a gene up to whole-genome sequencing. However, despite the widespread use of sequencing today, it was not until 1977 that Fredrick Sanger and his collaborators developed the chain-termination method to decode DNA sequences. It relies on the separation of a...
765.2K
Methods of Classification and Identification01:28

Methods of Classification and Identification

578
Bacterial identification relies on a diverse array of techniques to classify and understand microorganisms, each tailored to uncover specific characteristics. Traditional morphological approaches, while still valuable, are limited for closely related or structurally simple organisms. Modern methods integrate biochemical, serological, genetic, and advanced molecular tools to achieve greater accuracy.Morphological and Biochemical TechniquesMorphological characteristics, such as cell shape and...
578
Karyotyping01:17

Karyotyping

65.6K
Overview
65.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same journal

Shaping the future of bioscience education: trends, challenges and community insights.

Emerging topics in life sciences·2026
Same journal

Perceived impact of field trips on students' sense of community, skills and knowledge in Biosciences and Chemistry undergraduate degrees.

Emerging topics in life sciences·2026
Same journal

Clinical assessment meets laboratory science: adapting OSCE methodology for authentic biosciences evaluation in the age of generative AI.

Emerging topics in life sciences·2026
Same journal

A holistic approach to addressing the degree awarding gap: a perspective.

Emerging topics in life sciences·2026
Same journal

Integrating Smart Worksheets into mandatory pre-laboratory exercises increased exercise completion rates and laboratory test grades.

Emerging topics in life sciences·2026
Same journal

Marking the markers: evaluating the potential of professional development through collaborative marking circles.

Emerging topics in life sciences·2026
See all related articles

Related Experiment Video

Updated: Nov 10, 2025

Enhanced Genetic Analysis of Single Human Bioparticles Recovered by Simplified Micromanipulation from Forensic ‘Touch DNA’ Evidence
11:49

Enhanced Genetic Analysis of Single Human Bioparticles Recovered by Simplified Micromanipulation from Forensic ‘Touch DNA’ Evidence

Published on: March 9, 2015

16.3K

Developments in forensic DNA analysis.

Penelope R Haddrill1

  • 1Centre for Forensic Science, Department of Pure and Applied Chemistry, University of Strathclyde, Glasgow, U.K.

Emerging Topics in Life Sciences
|April 1, 2021
PubMed
Summary
This summary is machine-generated.

Forensic genetics advances enable DNA analysis of challenging samples. Novel methods like massively parallel sequencing and probabilistic genotyping improve intelligence from biological evidence in criminal investigations.

Keywords:
DNA profilingforensic biologyforensic genetics

More Related Videos

Application of DNA Fingerprinting using the D1S80 Locus in Lab Classes
08:35

Application of DNA Fingerprinting using the D1S80 Locus in Lab Classes

Published on: July 17, 2021

22.0K
Author Spotlight: Advancing DNA Extraction from Necrophilic Fly Samples using Simple Technique
06:33

Author Spotlight: Advancing DNA Extraction from Necrophilic Fly Samples using Simple Technique

Published on: May 3, 2024

712

Related Experiment Videos

Last Updated: Nov 10, 2025

Enhanced Genetic Analysis of Single Human Bioparticles Recovered by Simplified Micromanipulation from Forensic ‘Touch DNA’ Evidence
11:49

Enhanced Genetic Analysis of Single Human Bioparticles Recovered by Simplified Micromanipulation from Forensic ‘Touch DNA’ Evidence

Published on: March 9, 2015

16.3K
Application of DNA Fingerprinting using the D1S80 Locus in Lab Classes
08:35

Application of DNA Fingerprinting using the D1S80 Locus in Lab Classes

Published on: July 17, 2021

22.0K
Author Spotlight: Advancing DNA Extraction from Necrophilic Fly Samples using Simple Technique
06:33

Author Spotlight: Advancing DNA Extraction from Necrophilic Fly Samples using Simple Technique

Published on: May 3, 2024

712

Area of Science:

  • Forensic genetics
  • Molecular biology
  • Genetics

Background:

  • Traditional STR profiling has limitations with low quantity or degraded DNA.
  • Matching DNA profiles to databases or suspects is crucial in criminal investigations.
  • Novel forensic genetics methods offer solutions for challenging biological samples.

Purpose of the Study:

  • To review recent advances in forensic genetics.
  • To highlight methodologies for analyzing challenging forensic samples.
  • To discuss the implementation of innovations in forensic practice.

Main Methods:

  • Massively parallel sequencing for STR and other marker analysis.
  • Probabilistic genotyping for DNA mixture interpretation.
  • RNA and SNP profiling, epigenetics (DNA methylation), and forensic genetic genealogy.

Main Results:

  • Advanced techniques expand the utility of DNA analysis in forensics.
  • New methods provide intelligence on biological sample donors.
  • Innovations address limitations of traditional DNA profiling.

Conclusions:

  • Recent advances in forensic genetics offer powerful tools for criminal investigations.
  • Implementing these innovations requires careful consideration for maximizing benefits.
  • The field is rapidly evolving to tackle complex forensic challenges.