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Compounds Essential to Human Function01:25

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Opioid receptors, including the mu (μ, MOR), delta (δ, DOR), and kappa (κ, KOR) types, belong to the rhodopsin family of G protein-coupled receptors. These receptors are located throughout the central and peripheral nervous systems and in non-neuronal tissues such as macrophages and astrocytes. Opioid receptor ligands can be categorized into agonists or antagonists. Highly selective agonists include [d-Ala2, MePhe4, Gly(ol)5]-enkephalin or DAMGO for MOR, [D-Pen2,...
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Human Endogenous Natural Products.

Yingjie Bai1, Liyun Zhang1, Xiaoguang Lei2

  • 1Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Synthetic and Functional Biomolecules Center, College of Chemistry and Molecular Engineering, Peking University, 282 Chengfu Road, Haidian District, Beijing, China.

Progress in the Chemistry of Organic Natural Products
|April 1, 2021
PubMed
Summary
This summary is machine-generated.

Human cells and the microbiome produce natural products, vital compounds for health. This review covers endogenous human natural products and those from the microbiome, detailing new identification strategies.

Keywords:
DiseaseEndogenousHuman healthHuman microbiomeNatural products

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Area of Science:

  • Biochemistry
  • Microbiology
  • Human Physiology

Background:

  • Natural products are biosynthesized by living organisms, including endogenous compounds produced by human cells and the human microbiome.
  • Understanding these compounds is crucial for human health and disease research.

Purpose of the Study:

  • To review current knowledge on endogenous natural products synthesized by human cells.
  • To explore natural products generated by the human microbiome, including their co-metabolism.
  • To highlight advancements in identifying and characterizing microbiome-derived natural products.

Main Methods:

  • Literature review of endogenous and microbiome-derived natural products.
  • Discussion of key compound classes: amines, steroids, fatty acid derivatives, and metabolites of tryptophan, bile acids, choline, and cysteine.
  • Overview of novel strategies and technologies for natural product identification and functional analysis.

Main Results:

  • Detailed description of endogenous natural products from human cells (amines, steroids, fatty acid derivatives).
  • Explanation of microbiome-produced natural products involving specific metabolic pathways (tryptophan, bile acids, choline, cysteine).
  • Introduction of new technologies for characterizing microbiome-derived natural products' composition and function.

Conclusions:

  • Endogenous natural products from human cells and the microbiome play significant roles in human physiology.
  • Emerging strategies and technologies are enhancing our ability to study these complex natural products.
  • Further research into microbiome-derived natural products promises new insights into human health and disease.