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Curcumin-loaded core-shell biopolymer nanoparticles produced by the pH-driven method: Physicochemical and release
Zhenpeng Li1, Quanquan Lin1, David Julian McClements2
1School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou 310018, China.
Food Chemistry
|April 2, 2021
Summary
Core-shell biopolymer nanoparticles effectively encapsulate curcumin, enhancing its antioxidant activity and prolonging gastrointestinal release. This novel delivery system demonstrates stability across various conditions.
Area of Science:
- Biotechnology
- Materials Science
- Pharmacology
Background:
- Curcumin, a potent antioxidant, suffers from poor bioavailability.
- Developing effective delivery systems is crucial for enhancing curcumin's therapeutic potential.
Purpose of the Study:
- To fabricate and characterize core-shell biopolymer nanoparticles for curcumin encapsulation and delivery.
- To investigate the impact of coating composition on nanoparticle properties and curcumin release.
Main Methods:
- pH-driven fabrication of core-shell biopolymer nanoparticles.
- Fourier transform infrared spectroscopy and X-ray diffraction for structural analysis.
- Particle size, ζ-potential, and DPPH radical scavenging activity assays.
- In vitro gastrointestinal release studies.
Main Results:
- Curcumin was successfully encapsulated in an amorphous state within the nanoparticles.
- Nanoparticles exhibited excellent stability under long-term storage, heating, pH variations, and salt exposure.
- Encapsulation enhanced curcumin's DPPH radical scavenging activity.
- Prolonged gastrointestinal release of curcumin was observed.
Conclusions:
- Alginate and sodium caseinate coatings create a protective layer, enhancing nanoparticle stability and controlling curcumin release.
- The developed nanoparticles represent a promising system for improving curcumin's bioavailability and therapeutic efficacy.
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