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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

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CeO2 Nanoparticle-Containing Polymers for Biomedical Applications: A Review.

Alexander B Shcherbakov1, Vladimir V Reukov2, Alexander V Yakimansky3

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Advanced composite biomaterials merge polymers and nanoceria for enhanced biomedical uses. This combination improves drug delivery, tissue regeneration, and medical imaging, showcasing nanoceria

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Nanotechnology

Background:

  • Advanced composite biomaterials integrate polymers and metal oxide nanoparticles for biomedical applications.
  • Nanocrystalline cerium(IV) oxide (nanoceria) exhibits low toxicity and beneficial biological effects.
  • Combining nanoceria with polymers like PolyHEMA, polycaprolactone, chitosan, and cellulose enhances material properties.

Purpose of the Study:

  • To review recent advances in biomedical polymeric materials.
  • To highlight current applications of cerium oxide nanoparticles (nanoceria).
  • To explore the synergistic potential of polymer-nanoceria composites in biomedicine.

Main Methods:

  • Literature review of recent advancements in composite biomaterials.
  • Analysis of nanoceria's properties and biomedical potential.
  • Examination of polymer-nanoceria composite fabrication and applications.

Main Results:

  • Nanoceria enhances the bioavailability and efficacy of polymeric biomaterials.
  • Polymer-nanoceria composites show promise in tissue regeneration, drug delivery, and theranostics.
  • The combination mitigates potential negative effects of individual components.

Conclusions:

  • Nanoceria significantly boosts the biomedical potential of modern polymeric materials.
  • Polymer-nanoceria composites offer versatile solutions for diverse biomedical challenges.
  • Further research into these composites will drive innovation in regenerative medicine and beyond.