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Antimicrobial Actions and Applications of Chitosan
Cai-Ling Ke1, Fu-Sheng Deng1, Chih-Yu Chuang1
1Department of Biochemical Science and Technology, College of Life Science, National Taiwan University, Taipei 10617, Taiwan.
Abstract:
Chitosan is a naturally originating product that can be applied in many areas due to its biocompatibility, biodegradability, and nontoxic properties. The broad-spectrum antimicrobial activity of chitosan offers great commercial potential for this product. Nevertheless, the antimicrobial activity of chitosan varies, because this activity is associated with its physicochemical characteristics and depends on the type of microorganism. In this review article, the fundamental properties, modes of antimicrobial action, and antimicrobial effects-related factors of chitosan are discussed. We further summarize how microorganisms genetically respond to chitosan. Finally, applications of chitosan-based biomaterials, such as nanoparticles and films, in combination with current clinical antibiotics or antifungal drugs, are also addressed.
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