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Characterization of Functionally Associated miRNAs in Glioblastoma and their Engineering into Artificial Clusters for Gene Therapy
Published on: October 4, 2019
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Glioblastoma and MiRNAs
Swalih P Ahmed1, Javier S Castresana2, Mehdi H Shahi1
1Interdisciplinary Brain Research Centre, Faculty of Medicine, Aligarh Muslim University, Aligarh 202002, India.
Cancers
|April 3, 2021
Summary
MicroRNAs (miRNAs) show promise for glioblastoma (GB) treatment and diagnosis. This review explores their role in gene expression and pathways, offering new therapeutic avenues for this lethal brain tumor.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Glioblastoma (GB) is a lethal brain tumor with a poor prognosis, often resistant to current treatments like chemotherapy and radiotherapy.
- Existing therapies offer limited survival benefits, necessitating novel therapeutic strategies.
- MicroRNAs (miRNAs) are emerging as potential regulators in cancer development and progression.
Purpose of the Study:
- To provide a comprehensive overview of up-regulated and down-regulated miRNAs in glioblastoma.
- To examine the relationship between miRNA expression, gene expression, and cellular signaling pathways in GB.
- To explore the potential of miRNAs in glioblastoma diagnosis and treatment.
Main Methods:
- Literature review of studies investigating miRNA expression in glioblastoma.
- Analysis of miRNA roles in gene regulation and signaling pathways relevant to GB.
- Synthesis of current research on miRNA-based diagnostic and therapeutic approaches for GB.
Main Results:
- Specific miRNAs are found to be dysregulated (up-regulated or down-regulated) in glioblastoma.
- These miRNAs influence key genes and signaling pathways involved in GB proliferation and progression.
- miRNAs are implicated in both the development and potential inhibition of glioblastoma.
Conclusions:
- MicroRNAs represent a promising area for developing novel diagnostic tools and therapeutic interventions for glioblastoma.
- Further research is crucial to fully elucidate the complex roles of miRNAs in glioblastoma and optimize their clinical application.
- Combining miRNA-based strategies with conventional therapies like chemotherapy and radiotherapy may enhance treatment efficacy.
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