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Measurement of Tissue Oxygenation Using Near-Infrared Spectroscopy in Patients Undergoing Hemodialysis
Published on: October 2, 2020
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Changes in Intraocular Pressure During Hemodialysis: A Meta-analysis
Szu-Han Chen1, Da-Wen Lu2, Wan-Chen Ku3
1Departments of Physical Medicine and Rehabilitation.
Journal of Glaucoma
|April 4, 2021
Summary
Acetate dialysate previously elevated intraocular pressure (IOP) during hemodialysis (HD), but this is less common now. Glaucoma patients require caution due to potential IOP changes during HD.
Area of Science:
- Ophthalmology
- Nephrology
- Clinical Trials
Background:
- Acetate dialysate has been linked to increased intraocular pressure (IOP) during hemodialysis (HD).
- Previous studies on HD's impact on IOP have yielded conflicting results.
- Glaucoma and impaired aqueous outflow are known factors influencing intradialytic IOP.
Purpose of the Study:
- To systematically analyze the effect of hemodialysis on intraocular pressure.
- To identify potential moderators influencing intradialytic IOP changes.
Main Methods:
- A comprehensive meta-analysis of studies indexed in Medline, PubMed, Embase, Web of Science, and Cochrane.
- Inclusion of before-after studies reporting IOP changes during HD.
- Calculation of intradialytic IOP changes using four definitions and pooling of standardized mean differences (SMD) via a random-effects model.
Main Results:
- Overall data pooling revealed no significant intradialytic IOP rise.
- Subgroup analysis indicated an IOP rise before 1986 with acetate dialysate.
- An IOP decline was observed after 2005 with bicarbonate dialysate; glaucoma was an independent moderator.
Conclusions:
- The shift from acetate to bicarbonate dialysate has reduced the clinical issue of IOP elevation during HD.
- Physicians should remain vigilant regarding potential IOP fluctuations in hemodialysis patients with glaucoma.
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