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Using Published Health Utilities in Cost-Utility Analyses: Discrepancies and Issues in Cardiovascular Disease

Ting Zhou1,2, Zhiyuan Chen2, Hongchao Li1

  • 1School of International Pharmaceutical Business, China Pharmaceutical University, Nanjing, Jiangsu, China.

Medical Decision Making : an International Journal of the Society for Medical Decision Making
|April 5, 2021
PubMed

Insights

Discrepancies in health utilities used in cardiovascular disease cost-utility analyses (CUAs) are common. Authors must cite original studies and be transparent about utility selection to ensure CUA credibility.

Area of Science:

  • Health economics
  • Medical decision making
  • Cardiovascular disease research

Background:

  • Health utilities are crucial for quality-adjusted life years in cost-utility analysis (CUA).
  • Improper use of published health utilities can undermine CUA credibility.

Purpose of the Study:

  • To identify and analyze discrepancies in the application of published health utilities within cardiovascular disease (CVD) cost-utility analyses.

Main Methods:

  • Reviewed 585 CVD CUAs from the Tufts Cost-Effectiveness Analysis Registry.
  • Compared 2235 health utilities from 442 CUAs against 203 original utility studies.
  • Utilized logistic regression to identify factors predicting discrepancies.

Main Results:

  • Only 26.7% of health utilities matched original descriptions and values.
  • 44.3% differed in both description and value, often due to disease severity.
  • 87.4% of value discrepancies lacked justification.

Conclusions:

  • Significant discrepancies exist in health utility usage for CVD CUAs.
  • Authors must reference original utility studies and ensure transparency in selection and application.
  • Accurate health utility reporting is essential for reliable cost-utility analyses.
Abstract

Keywords:
cardiovascular diseasecost-utility analysishealth utilityquality

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