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Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
Published on: January 21, 2020
MORPHOLOGICAL CHANGES IN PERIODONTAL TISSUE DURING PERIODONTITIS
S Kvaratskhelia1, T Nemsadze1, S Puturidze1
1Ivane Javakhishvili Tbilisi State University, Georgia.
Abstract:
Periodontitis is the most common oral disease worldwide and is the leading cause of tooth loss. It is considered to be a major burden in terms of costs of treatment and preventive measures. According to the systematic reviews, there is a link between periodontitis and cancer. In particular, patients diagnosed with periodontitis have a higher risk of developing oral cancer. In this regard, the histomorphological examination of patients with periodontitis, which has not yet been sufficiently introduced in dental practice, is acquiring more and more importance. The aim of the work is a morphological study of periodontal tissues in patients with severe generalized periodontitis in Georgia - to identify signs of possible precancerous lesions. The data obtained show that the morphological characteristic of severe periodontitis is purulent destructive inflammation. In addition, a third of severe periodontitis is accompanied by mild to moderate epithelial dysplasia, which should be taken into account when choosing a treatment method in terms of oncological alertness.
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