PECULIARITIES OF EVALUATION OF THE ORAL FLUID ANTIOXIDANT ACTIVITY IN PATIENTS WITH LOCAL OR SYSTEMIC DISEASES.

Area of Science:

• Biochemistry
• Oral Medicine
• Pathophysiology

Background:

• Interpreting oxidative homeostasis in oral fluid presents challenges due to multidirectional changes in blood and saliva.
• Assessing total antioxidant activity (TAA) requires a nuanced approach to differentiate disease states.

Purpose of the Study:

• To analyze difficulties in interpreting oxidative homeostasis of oral fluid.
• To propose a parallel assessment method for blood plasma and oral fluid TAA dynamics.
• To correlate TAA changes with different nosological forms.

Main Methods:

• Parallel assessment of total antioxidant activity (TAA) in blood plasma and oral fluid.
• Studied four patient groups: maxillofacial phlegmons, partial tooth absence, type 2 diabetes mellitus, and pelvic inflammatory diseases.

Main Results:

• Simultaneous decrease in TAA (blood and oral fluid) indicates systemic chronic diseases with metabolic disorders (e.g., type 2 diabetes).
• Decreased TAA (blood) with unchanged TAA (oral fluid) suggests localized somatic diseases without maxillofacial involvement (e.g., uterine inflammation).
• Increased TAA (oral fluid) with normal/low TAA (blood) is characteristic of dental diseases, potentially due to cellular content leaching.

Conclusions:

• Parallel TAA assessment aids in differentiating systemic from localized pathologies.
• Oral fluid TAA changes can reflect the extent of the pathological process, from localized dental issues to systemic conditions.
• This method offers improved diagnostic interpretation for oxidative homeostasis in various diseases.