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A histidine-rich protein from Plasmodium falciparum and its interaction with membranes

A Kilejian, J B Jensen

    Bulletin of the World Health Organization
    |January 1, 1977
    PubMed

    Insights

    A histidine-rich protein, potentially aiding merozoite invasion, was found in Plasmodium falciparum. This protein is similar to one from Plasmodium lophurae but has a higher molecular weight.

    Area of Science:

    • Malariology
    • Parasitology
    • Protein Biochemistry

    Background:

    • Previous research identified a histidine-rich protein in Plasmodium lophurae.
    • This protein was hypothesized to play a role in malaria parasite invasion of red blood cells.

    Purpose of the Study:

    • To investigate the presence and characteristics of a similar histidine-rich protein in Plasmodium falciparum.
    • To compare the properties of this protein with the one found in Plasmodium lophurae.

    Main Methods:

    • Isolation and characterization of proteins from Plasmodium falciparum.
    • Analysis of protein solubility and molecular weight.

    Main Results:

    • A histidine-rich protein was detected in Plasmodium falciparum.
    • The Plasmodium falciparum histidine-rich protein is soluble in acid.
    • The identified protein exhibits a slightly higher molecular weight compared to the Plasmodium lophurae counterpart.

    Conclusions:

    • Plasmodium falciparum possesses a histidine-rich protein analogous to that found in Plasmodium lophurae.
    • This protein's characteristics suggest a conserved function in erythrocyte invasion across Plasmodium species.

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