Related Experiment Video
Updated: Nov 10, 2025

Exploring the Arginine Methylome by Nuclear Magnetic Resonance Spectroscopy
Published on: December 16, 2021
Asymmetric dimethylarginine in psychiatric disorders
Daniel Braun1, Jens Schlossmann2, Ekkehard Haen1
1Clinical Pharmacology, Department of Pharmacology and Toxicology, University of Regensburg, Universitätsstrasse 31, 93053 Regensburg, Germany.
Abstract:
Serum concentrations of asymmetric dimethylarginine (ADMA) in patients with schizophrenia, schizoaffective disorder, bipolar disorder, and depression were determined and compared to serum concentrations in healthy individuals. In all psychiatric diseases investigated, the ADMA concentration was elevated compared to the control group. Patients with recurrent depressive disorder had higher ADMA levels than patients with only one depressive episode. No differences between women and men were found. The elevated ADMA levels suggest that ADMA is involved in the pathophysiology of psychiatric diseases.
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