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Signal Acquisition, Score Interpretation, and Economics of a Non-Invasive Point-of-Care Test for Coronary Artery Disease
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Assessment of COVID-19 deaths from cardiological perspective

Timor Omar1, Muammer Karakayalı1, Gökhan Perincek2

  • 1Department of Cardiology, M.D. Kars Harakani State Hospital, Kars, Turkey.

Acta Cardiologica
|April 7, 2021
PubMed

Insights

COVID-19 cardiac injury, indicated by elevated high-sensitivity troponin T (hs-TnT) and ECG abnormalities, significantly increases in-hospital mortality risk. Early identification and aggressive treatment are crucial for high-risk patients.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Internal Medicine

Background:

  • COVID-19 is associated with diverse cardiac complications and electrocardiographic (ECG) abnormalities.
  • Assessing cardiological parameters is vital for understanding COVID-19 patient outcomes.

Purpose of the Study:

  • To analyze cardiological parameters, including ECG and high-sensitivity troponin T (hs-TnT), in hospitalized COVID-19 patients.
  • To determine the association between these parameters and in-hospital mortality.

Main Methods:

  • Retrospective analysis of 453 hospitalized COVID-19 patients with known outcomes.
  • Comparison of demographic, comorbidity, laboratory, and ECG findings between survivors and non-survivors, and between cardiac injury and no-cardiac injury subgroups.

Main Results:

  • Cardiac injury was linked to significantly higher in-hospital mortality.
  • Patients with cardiac injury showed increased frequencies of atrial fibrillation, axis change, ST-segment/T-wave changes, fragmented QRS, and premature contractions.
  • Non-survivors exhibited longer QRS intervals, more frequent ST-segment/T-wave changes, and an isolated S1Q3T3 pattern. Elevated hs-TnT levels at admission were markedly higher in non-survivors.
  • hs-TnT, age, and respiratory rate were independent predictors of mortality. Comorbidities were more prevalent in non-survivors and the cardiac injury group.

Conclusions:

  • Elevated hs-TnT and ECG abnormalities indicating cardiac involvement on admission predict poor prognosis and increased in-hospital mortality in COVID-19 patients.
  • Prioritized and aggressive therapeutic strategies are recommended for these high-risk patients to reduce mortality.
Abstract

Keywords:
COVID-19electrocardiogrammortalitytroponin

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