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Updated: Nov 10, 2025
10:39
3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
Published on: June 2, 2014
18.5K
[New Management of Cluster Headache]
1Department of Neurology, Japanese Red Cross Shizuoka Hospital.
Brain and Nerve = Shinkei Kenkyu No Shinpo
|April 7, 2021
Summary
Galcanezumab, a CGRP monoclonal antibody, is FDA-approved for preventing cluster headaches. Sphenopalatine ganglion stimulation is effective for acute cluster headache treatment, with both showing safety in clinical trials.
Area of Science:
- Neurology
- Pharmacology
Background:
- Cluster headaches are a debilitating neurological condition.
- Current treatments for cluster headaches have limitations.
Purpose of the Study:
- To review the efficacy and safety of Galcanezumab for cluster headache prevention.
- To examine sphenopalatine ganglion stimulation as an acute treatment for cluster headache.
- To discuss the clinical applications and future prospects of these therapies in Japan.
Main Methods:
- Review of randomized, double-blind, placebo-controlled trials for Galcanezumab.
- Analysis of randomized, controlled trials for sphenopalatine ganglion stimulation.
- Examination of clinical trial results, mechanisms of action, and clinical uses.
Main Results:
- Galcanezumab demonstrated effectiveness and safety in preventing recurrent cluster headaches.
- Sphenopalatine ganglion stimulation proved effective and safe for acute treatment of chronic cluster headache.
- Both therapies represent significant advancements in cluster headache management.
Conclusions:
- Galcanezumab and sphenopalatine ganglion stimulation offer novel therapeutic options for cluster headache patients.
- Further research and clinical implementation are warranted, particularly regarding prospects in Japan.
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