Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Genomics

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Study Protocol to Characterize Symptom Experience During Immune Checkpoint Inhibitor Therapy for Cutaneous Melanoma.

Nursing research·2026

Same author

Consensus co-expression analysis identifies a common set of co-expressed genes associated with diabetic peripheral neuropathy and chemotherapy-induced peripheral neuropathy.

Molecular pain·2026

Same author

Consensus Co-Expression Analysis Identifies A Common Set Of Co-Expressed Genes Associated With Diabetic Peripheral Neuropathy And Chemotherapy-Induced Peripheral Neuropathy.

bioRxiv : the preprint server for biology·2025

Same author

Alternative Splicing And Global Transcriptome Changes Associated With LPS Stimulation In Human Peripheral Blood Mononuclear Cells.

bioRxiv : the preprint server for biology·2025

Same author

Cytokine-Cytokine Receptor Interaction and Endocytosis are Common Pathways for Symptom Burden and Sickness Behavior Symptoms in Oncology Patients Undergoing Chemotherapy.

Cancer medicine·2025

Same author

Advancing Global Cancer Symptom Science: Insights and Strategies From the Inaugural Cancer Symptom Science Expert Meeting.

Nursing research·2025

Search research articles

Related Experiment Video

Updated: Nov 9, 2025

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts

Published on: September 20, 2024

Multi-Staged Data-Integrated Multi-Omics Analysis for Symptom Science Research.

Carolyn S Harris¹, Christine A Miaskowski^1,2, Anand A Dhruva²

¹School of Nursing, 8785University of California, San Francisco, CA, USA.

Biological Research for Nursing

|April 8, 2021

Summary

This summary is machine-generated.

Multi-staged data-integrated multi-omics (MS-DIMO) analysis enhances symptom science by combining diverse omics data. This approach offers a comprehensive view of molecular mechanisms underlying symptoms, aiding in hypothesis refinement and therapeutic target discovery.

Keywords:

cross-validation gene expression genomics methylation multi-omics symptom

More Related Videos

Author Spotlight: Advancing Alzheimer's Research – Exploring Early Detection and Multi-Omics Approaches

Author Spotlight: Advancing Alzheimer's Research – Exploring Early Detection and Multi-Omics Approaches

Published on: December 15, 2023

Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies

Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies

Published on: September 15, 2023

Related Experiment Videos

Last Updated: Nov 9, 2025

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts

Published on: September 20, 2024

Author Spotlight: Advancing Alzheimer's Research – Exploring Early Detection and Multi-Omics Approaches

Author Spotlight: Advancing Alzheimer's Research – Exploring Early Detection and Multi-Omics Approaches

Published on: December 15, 2023

Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies

Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies

Published on: September 15, 2023

Area of Science:

Symptom science
Molecular biology
Bioinformatics

Background:

Omics approaches provide insights into molecular mechanisms of symptoms.
Current symptom science research often relies on single omics analyses, limiting comprehensive understanding.
Limitations include data confined to specific omics domains like genomics or transcriptomics.

Purpose of the Study:

To describe a multi-staged data-integrated multi-omics (MS-DIMO) analysis using "Symptom X" as an example.
To discuss challenges in single omics analyses and how MS-DIMO addresses them.
To review omics data integration orders, analysis tools, and case exemplars in symptom science.

Main Methods:

Integration of multiple omics data types within a single study.
Application of a multi-staged data-integrated multi-omics (MS-DIMO) framework.
Utilizing "Symptom X" as a case study for MS-DIMO analysis.

Main Results:

MS-DIMO analysis provides a more comprehensive understanding of complex biological mechanisms.
Refinement of mechanistic hypotheses related to symptoms.
Identification of potential therapeutic targets for specific symptoms.

Conclusions:

MS-DIMO analysis strengthens symptom science research.
Prioritization of functional genes and biological processes associated with symptoms.
Enables a holistic view of symptom etiology through integrated omics data.