Multiple Primary Melanomas in a Young Patient.

Area of Science:

• Oncology
• Dermatology
• Genetics

Background:

• Multiple primary melanomas (MPM) are a rare clinical finding.
• The incidence of a second primary melanoma ranges from 0.2% to 8.7%.
• The occurrence of more than four primary melanomas is exceptionally rare.

Purpose of the Study:

• To report a rare case of a patient with four primary cutaneous melanomas and visceral metastases.
• To discuss the implications of multiple primary melanomas.
• To emphasize the importance of lifelong dermatologic surveillance and genetic counseling.

Main Methods:

• Clinical presentation of a 45-year-old male with a large scalp nodule and multiple atypical melanocytic lesions.
• Histopathological examination confirming primary cutaneous melanoma.
• Total body computed tomography revealing visceral metastases.

Main Results:

• The patient was diagnosed with four primary cutaneous melanomas and extensive visceral metastases.
• Despite the diagnosis, the patient declined genetic testing.
• The patient was referred for oncological treatment and advised lifelong dermatologic screening.

Conclusions:

• The etiology of MPM, whether genetic susceptibility or environmental factors, requires further elucidation.
• Patients with MPM necessitate rigorous, lifelong dermatologic surveillance.
• Genetic testing should be considered for individuals diagnosed with multiple primary melanomas.