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Updated: Aug 18, 2026

Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells
Published on: February 21, 2014
Relationships between polyamine, deoxyribonucleic acid and oestrogen receptor binding site concentrations in human
J C Norman1, J R Puddefoot, E Anderson
1Department of Chemical Pathology, St Mary's Hospital Medical School, London, U.K.
Abstract:
Concentrations of polyamines, DNA and oestrogen receptor (ER) binding sites have been estimated in 23 malignant and 2 benign breast tumours. Polyamine and DNA concentrations, expressed per unit wet weight of tissue, were significantly higher in ER-poor (less than 10 fmol/mg cytosol protein) than in ER-rich tumours. Spermidine/spermine ratios were similar in ER-poor and ER-rich tumours. There was a relationship between polyamine and DNA levels and when polyamine concentrations were expressed per unit weight of DNA those in ER-poor tumours did not differ from those in ER-rich tumours. Possible reasons for these findings are discussed.
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