Relationships between polyamine, deoxyribonucleic acid and oestrogen receptor binding site concentrations in human

J C Norman1, J R Puddefoot, E Anderson

  • 1Department of Chemical Pathology, St Mary's Hospital Medical School, London, U.K.

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The Nucleolus

The nucleolus is the most prominent substructure of the nucleus. When it was first discovered, it was considered to be an isolated organelle that forms fibrils and granules. In 1931, the relationship between the nucleolus and chromosomes was first described by Heitz. He observed that the appearance and size of nucleolus varies depending on the stage of the cell cycle. He also noticed constricted regions on different chromosomes clustered together at definite cell cycle stages. These regions,...