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Effect of cadmium on protein-ascorbate metabolism in the protein restricted rat
K Pharikal1, P C Das, S Dasgupta
1University College of Science & Technology, Biochemistry and Nutrition Research Laboratory, Calcutta, India.
Abstract:
Daily administration of cadmium chloride (0.3 mg/100 g of body weight) subcutaneously for 14 days in adult Sprague-Dawley rats led to a decrease in the concentration of protein and ascorbic acid in the liver, plasma and brain regions both in normal protein and in protein restricted dietary condition. Therefore, it might be presumed that the changes in protein and ascorbic acid in both the experimental animal groups alters the metabolic state of the brain affecting neuronal activity.