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Related Experiment Video

Updated: Nov 9, 2025

Author Spotlight: Non-Surgical Treatment of Melasma&#8211; Microneedling with Tranexamic Acid
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Melasma treatment: a systematic review.

Nicoleta Neagu1, Claudio Conforti2, Marina Agozzino2

  • 1State Clinic of Dermatology, Mureș County Hospital, Tîrgu Mureș, Romania.

The Journal of Dermatological Treatment
|April 14, 2021
PubMed
Summary
This summary is machine-generated.

Melasma treatment is challenging due to high recurrence. Combination therapies show the best results for this common pigmentation disorder, improving quality of life.

Keywords:
Melasmaintense pulsed lightlasermicroneedlingpeelingtranexamic acid

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Area of Science:

  • Dermatology
  • Pigmentation Disorders

Background:

  • Melasma is a chronic, refractory pigmentation disorder common in darker skin types.
  • Its prevalence ranges from 8.8% to 40%, significantly impacting quality of life.
  • Current therapeutic management is challenging with high recurrence rates.

Purpose of the Study:

  • To review the efficacy of various melasma treatments.
  • To identify optimal treatment strategies for melasma subtypes.

Main Methods:

  • Review of systemic treatments (tranexamic acid, Polypodium leucotomos).
  • Evaluation of procedural treatments (microneedling, peeling, laser, light devices).
  • Assessment of combination therapies versus single treatments.

Main Results:

  • Systemic and procedural treatments show efficacy, but superiority over hydroquinone is not established.
  • Laser and light devices offer benefits, yet recurrence rates remain high.
  • Combination therapies (double or triple) yield superior outcomes compared to single therapies.

Conclusions:

  • No single treatment is universally effective for melasma.
  • Combination therapies are most effective, necessitating personalized treatment plans.
  • Wood's lamp and dermatoscopic evaluations are crucial for selecting targeted melasma treatments.