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Updated: Nov 9, 2025

Quantitative Magnetic Resonance Imaging of Skeletal Muscle Disease
Published on: December 18, 2016
Basics of magnetic resonance imaging and quantitative parameters T1, T2, T2*, T1rho and diffusion-weighted imaging
1Department of Radiology, Children's Hospital of Philadelphia, 3401 Civic Center Blvd., Philadelphia, PA, 19104, USA. serais@chop.edu.
Abstract:
Magnetic resonance imaging is widely available and accepted as the imaging method of choice for many pediatric body imaging applications. Traditionally, it has been used in a qualitative way, where the images are reported non-numerically by radiologists. But now MRI machines have built-in post-processing software connected to the scanner and the database of MR images. This setting enables and encourages simple quantitative analysis of MR images. In this paper, the author reviews the fundamentals of MRI and discusses the most common quantitative MRI techniques for body imaging: T1, T2, T2*, T1rho and diffusion-weighted imaging (DWI). For each quantitative imaging method, this article reviews the technique, its measurement mechanism, and selected clinical applications to body imaging.
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