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Area of Science:

  • Oncology
  • Neurology
  • Cancer Therapeutics

Background:

  • Neuropathy is a common complication in cancer patients, manifesting at various disease stages.
  • Peripheral nerve involvement, often in a stocking-glove distribution, is frequently observed.
  • Causes include chemotherapy, immune checkpoint inhibitors, paraneoplastic syndromes, tumor infiltration, and radiation.

Purpose of the Study:

  • To summarize the causes and clinical presentations of neuropathy in cancer patients.
  • To highlight the spectrum of neurological complications associated with cancer and its treatment.

Main Methods:

  • Literature review of studies on cancer-related neuropathy.
  • Analysis of reported cases and treatment outcomes.

Main Results:

  • Chemotherapy-induced peripheral neuropathy (CIPN) is the most prevalent form.
  • Immune checkpoint inhibitors are increasingly recognized as a cause of neuropathy.
  • Other significant causes include paraneoplastic syndromes and direct tumor effects.

Conclusions:

  • Neuropathy in cancer patients has diverse etiologies, necessitating comprehensive diagnostic evaluation.
  • Management strategies involve treating the primary cancer and alleviating neuropathic pain.