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Updated: Nov 9, 2025

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Published on: January 27, 2021
Determination of a quantitative relationship between material properties, process settings and screw feeding behavior
B Bekaert1, L Penne1, W Grymonpré2
1Laboratory of Pharmaceutical Technology, Department of Pharmaceutics, Ghent University, Ottergemsesteenweg 460, B-9000 Ghent, Belgium.
This study establishes a predictive model for high-throughput powder feeder performance by linking material properties to feeding behavior. This reduces the need for extensive experimental trials, optimizing powder feeding processes.
Area of Science:
- Powder Technology
- Chemical Engineering
- Materials Science
Background:
- Accurate powder feeding is critical in pharmaceutical and chemical industries.
- Predicting feeder performance based on material properties remains a challenge.
Purpose of the Study:
- To establish a quantitative relationship between powder properties, process settings, and feeder performance.
- To develop predictive models for high-throughput powder feeders.
- To reduce the number of required feeding experiments through predictive modeling.
Main Methods:
- Multivariate modeling (Partial Least Squares - PLS) was employed.
- Thirteen diverse powders were characterized for 44 material properties.
- Volumetric and gravimetric feeder trials were conducted to measure feeding responses.
Main Results:
- PLS models demonstrated clear correlations between material properties, process settings, and feeding behavior.
- Screw type and speed significantly influenced volumetric feeding.
- Optimized process parameters (filters, vibrations, agitator control) reduced feeding variability.
Conclusions:
- The developed models enable prediction of feeder performance for various materials.
- Characterization of a subset of material properties can predict feeding performance.
- This approach significantly reduces the experimental effort required for feeder optimization.
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