Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Statistical method for rapid homology search.

A A Mironov1, N N Alexandrov

  • 1Institute for Genetics of Microorganisms, Moscow, USSR.

Nucleic Acids Research
|June 10, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Strong-field ionization in particle-in-cell simulations.

Physical review. E·2025
Same author

Fastq-dupaway: a fast and memory-efficient tool for deduplication of single- and paired-end NGS data.

Scientific reports·2025
Same author

Integration of HiMoRNA and RNAChrom: Validation of the Functional Role of Long Non-coding RNAs in the Epigenetic Regulation of Human Genes Using RNA-Chromatin Interactome Data.

Acta naturae·2025
Same author

Multiplicity of electron- and photon-seeded electromagnetic showers at multipetawatt laser facilities.

Physical review. E·2025
Same author

RNA-Chrom: a manually curated analytical database of RNA-chromatin interactome.

Database : the journal of biological databases and curation·2023
Same author

[RNA-Chromatin Interactome: What? Where? When?]

Molekuliarnaia biologiia·2022
Same journal

Correction to 'scSuperAnnotator: A platform for benchmarking comparison and visualizing automated cellular annotation methods for scRNA-seq data'.

Nucleic acids research·2026
Same journal

Correction to 'Differentiable partition function calculation for RNA'.

Nucleic acids research·2026
Same journal

Deployment of non-canonical splicing in tunicate genomes is mediated by divergent U2AF function and changing m6A modification in U1 and U6 snRNA.

Nucleic acids research·2026
Same journal

Bacillus subtilis DnaB forms multiple protein-protein interactions essential for DNA replication initiation.

Nucleic acids research·2026
Same journal

Multiple forms of protein-protein and DNA binding are exhibited by BrxC from the BREX phage restriction system.

Nucleic acids research·2026
Same journal

Biosynthesis of glycosylated 5-hydroxycytosine in the DNA of diverse viruses.

Nucleic acids research·2026
See all related articles

A novel DNA sequence homology search method identifies weak homologies, including those with mutations and deletions. This approach is significantly faster than dynamic programming, enabling large-scale nucleotide bank searches on personal computers.

Area of Science:

  • Bioinformatics
  • Computational Biology
  • Genomics

Background:

  • Homology searching is crucial for understanding DNA sequence function and evolution.
  • Existing dynamic programming algorithms can be computationally intensive for large datasets.

Purpose of the Study:

  • To introduce a new, efficient method for DNA sequence homology searching.
  • To enable the detection of weak and extensive homologies, including those with mutations and deletions.

Main Methods:

  • Development of a novel algorithm for sequence comparison.
  • Implementation of the algorithm for practical application in bioinformatics.

Main Results:

  • The new method effectively identifies homologies missed by traditional approaches.

Related Experiment Videos

  • The algorithm demonstrates a significant speed improvement (at least two orders of magnitude) over dynamic programming.
  • The method is suitable for comprehensive nucleotide bank searches using personal computers.

    • Conclusions:

    • This new homology search method offers a substantial advancement in speed and sensitivity.
    • It democratizes large-scale genomic data analysis by enabling personal computer utilization.