Related Experiment Video
Updated: Nov 8, 2025
07:12
Author Spotlight: Using Point-of-Care Ultrasound for Comprehensive Evaluation of the Abdominal Aorta
Published on: September 8, 2023
3.5K
Concerns About Fluoroquinolones and Aortic Aneurysm.
1Diane S. Aschenbrenner is an assistant professor at Notre Dame of Maryland University in Baltimore. She also coordinates Drug Watch : daschenbrenner@ndm.edu .
The American Journal of Nursing
|April 19, 2021
Summary
Fluoroquinolone antibiotics may increase the risk of aortic aneurysm in all adults, not just those with pre-existing risk factors. This finding broadens the understanding of potential adverse drug events.
Area of Science:
- Pharmacology
- Cardiovascular Medicine
- Public Health
Background:
- Fluoroquinolones are broad-spectrum antibiotics with known serious side effects.
- Aortic aneurysms are life-threatening vascular conditions.
- Previous research suggested a link between fluoroquinolones and aortic aneurysm, primarily in high-risk individuals.
Purpose of the Study:
- To investigate the association between fluoroquinolone use and aortic aneurysm risk across a broader adult population.
- To determine if fluoroquinolone-associated aortic aneurysm risk extends beyond individuals with established risk factors.
Main Methods:
- Retrospective cohort study design.
- Analysis of large healthcare databases to identify patients prescribed fluoroquinolones.
- Comparison of aortic aneurysm incidence between fluoroquinolone users and non-users.
- Adjustment for potential confounding variables and pre-existing risk factors.
Main Results:
- An increased risk of aortic aneurysm was observed in adults following fluoroquinolone exposure.
- This elevated risk was present even in individuals without traditional aortic aneurysm risk factors.
- The findings suggest a potential class-wide effect of fluoroquinolones on aortic integrity.
Conclusions:
- Fluoroquinolone antibiotic use may represent a risk factor for aortic aneurysm development in the general adult population.
- Healthcare providers should consider this broadened risk profile when prescribing fluoroquinolones.
- Further research is warranted to elucidate the mechanisms underlying this association.
More Related Videos
06:59Improved Registration of 3D CT Angiography with X-ray Fluoroscopy for Image Fusion During Transcatheter Aortic Valve Implantation
Published on: June 3, 2018
10.8K
04:08Fluorescence Angiography for Evaluation of Aneurysm Perfusion and Parent Artery Patency in Rat and Rabbit Aneurysm Models
Published on: July 24, 2019
7.2K
Related Concept Videos
01:21Aneurysm II: Clinical Manifestations and Diagnostic Studies
64
Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
64
01:25Aortic Regurgitation III: Medical Management
133
Aortic regurgitation (AR) is when the aortic valve does not close or seal properly, leading to backward blood circulation from the aorta into the left ventricle during diastole. Common causes of AR include rheumatic heart disease, congenital valve defects, and aortic root dilation. Managing AR requires a multifaceted approach to alleviate symptoms, preserve left ventricular function, and address the underlying cause of the regurgitation. Patients with symptomatic AR or significant left...
133
01:30Aneurysm I: Introduction
101
An aortic aneurysm is a localized outpouching or dilation at a weak point in the artery wall. It may involve different parts of the aorta, such as the abdominal aorta, aortic arch, or thoracic aorta.Etiological factorsSeveral disorders are associated with aortic aneurysms.Congenital causes, such as primary connective tissue disorders like Marfan syndrome, impact the integrity and strength of connective tissues, notably affecting the aorta. Marfan syndrome is a genetic disorder that specifically...
101
01:26Aneurysm III: Interprofessional Care
83
Aneurysm management involves either conservative medical therapy or surgical intervention, depending on the size and symptoms of the aneurysm. Conservative management is generally reserved for smaller, asymptomatic aneurysms, while larger or symptomatic aneurysms often necessitate surgical repair.Conservative Medical TherapyFor small, asymptomatic aneurysms, particularly abdominal aortic aneurysms (AAA) less than 5.5 centimeters in diameter, conservative medical therapy is recommended. This...
83
01:22Aneurysm IV: Nursing Management
147
Vigilant monitoring for aneurysm rupture is essential for patients undergoing aortic surgery.Preoperative Nursing ManagementContinuously monitor the patient for manifestations of aneurysm rupture, such as pallor, weakness, tachycardia, hypotension, abdominal, back, groin, or periumbilical pain, changes in consciousness, and a pulsating abdominal mass. Regularly assess the patient's peripheral pulses.Instruct the patient to consume a clear liquid diet the day before surgery and administer...
147
01:22Aortic Regurgitation II: Clinical Features and Diagnostic Tests
153
Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
153