Hybrid quantum annealing via molecular dynamics
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Updated: Nov 8, 2025

Author Spotlight: In Silico Creation and Impact of Carbonylated Amino Acids on Protein Structure and Function
Published on: April 26, 2024
Hirotaka Irie1,2, Haozhao Liang3,4, Takumi Doi5,3
1AI R&I Division, Advanced Research and Innovation Center, DENSO CORPORATION, Global R & D Tokyo, Tokyo, 108-0075, Japan. hirotaka.irie.j3a@jp.denso.com.
Abstract:
A novel quantum-classical hybrid scheme is proposed to efficiently solve large-scale combinatorial optimization problems. The key concept is to introduce a Hamiltonian dynamics of the classical flux variables associated with the quantum spins of the transverse-field Ising model. Molecular dynamics of the classical fluxes can be used as a powerful preconditioner to sort out the frozen and ambivalent spins for quantum annealers. The performance and accuracy of our smooth hybridization in comparison to the standard classical algorithms (the tabu search and the simulated annealing) are demonstrated by employing the MAX-CUT and Ising spin-glass problems.
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