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Updated: Nov 8, 2025

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Published on: March 3, 2023
Pleural effusion in hematological pathology
Neeraja Yerrapotu1, Abid Rahman1, Ali Gabali1
1Department of Pathology, Detroit Medical Center, Karmanos Cancer Center and Wayne State University School of Medicine, Detroit, Michigan, United States.
Abstract:
A 51-year-old male with a history of chronic myelomonocytic leukemia-2 (CMML-2) presented with fatigue, night sweats, dyspnea, and right-sided chest pain exacerbated by deep breath. Computed tomography scan demonstrated right-sided pleural effusion with atelectasis. Pleural fluid cytology showed reactive mesothelial cells mixed with atypical cells [Figure 1]. The immunostains are performed using the SCIP approach.[1] The atypical cells were immunoreactive for vimentin, CD68, and CD163, while non-immunoreactive for cytokeratin, calretinin, BerEP4, and MOC31.
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