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Targeting STAT3: A crucial modulator of sepsis

Wangrui Lei1,2, Dianxiao Liu3, Meng Sun4

  • 1Xi'an Key Laboratory of Cardiovascular and Cerebrovascular Diseases, Xi'an No.3 Hospital, School of Life Sciences and Medicine, Northwest University, Xi'an, China.

Journal of Cellular Physiology
|April 22, 2021
PubMed

Insights

Signal transducer and activator of transcription 3 (STAT3) plays a key role in inflammatory responses. Targeting STAT3 shows promise as a therapeutic strategy for sepsis treatment and as a potential biomarker.

Area of Science:

  • Molecular Biology
  • Immunology
  • Critical Care Medicine

Background:

  • Signal transducer and activator of transcription 3 (STAT3) is a crucial transcription factor involved in cellular responses to cytokines and growth factors.
  • STAT3 regulates genes critical for both pro- and anti-inflammatory processes, impacting overall immune homeostasis.
  • Sepsis, a life-threatening condition characterized by dysregulated host response to infection, involves complex inflammatory pathways where STAT3 acts as a central mediator.

Purpose of the Study:

  • To review and evaluate existing literature on the role of STAT3 in experimental and clinical sepsis.
  • To assess the therapeutic potential of targeting STAT3 for sepsis treatment.
  • To explore STAT3's utility as a potential biomarker for sepsis.

Main Methods:

  • Comprehensive literature search of studies investigating STAT3 in sepsis.
  • Analysis of experimental models and clinical data related to STAT3 modulation in sepsis.
  • Synthesis of findings regarding STAT3's involvement in sepsis pathophysiology and treatment.

Main Results:

  • Accumulating evidence highlights STAT3 as a key player in the complex network of inflammatory pathways during sepsis.
  • Studies indicate that modulating STAT3 activity can influence sepsis outcomes in experimental settings.
  • The literature suggests a potential role for STAT3 in both the development and progression of sepsis.

Conclusions:

  • Targeting STAT3 presents a promising therapeutic avenue for managing sepsis.
  • STAT3 holds potential as a valuable biomarker for sepsis diagnosis or prognosis.
  • Further research is warranted to fully elucidate STAT3's role and optimize its therapeutic targeting in sepsis.
Keywords:
STAT3Sepsisapoptosisautophagyimmune responseinflammation

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