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Updated: Nov 8, 2025

Author Spotlight: Streamlining Rice Breeding with CRISPR/Cas for Obtaining Optimal Phenotypic and Agronomic Traits
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Perspectives for epigenetic editing in crops.

S Selma1, D Orzáez2

  • 1Instituto de Biología Molecular Y Celular de Plantas (IBMCP), Consejo Superior de Investigaciones Científicas, Universidad Politécnica de Valencia, Camino Vera s/n, 46022, Valencia, Spain.

Transgenic Research
|April 23, 2021
PubMed
Summary
This summary is machine-generated.

CRISPR/Cas technology enables targeted epigenomic modifications in plants by fusing epigenetic effectors to DNA-binding proteins. This approach allows for precise control over gene expression, impacting plant biotechnology and crop breeding.

Keywords:
CRISPR/CasCrop improvementEpigeneticsProgrammable epigenetic editors

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Area of Science:

  • Plant biotechnology
  • Epigenetics
  • Molecular biology

Background:

  • Site-specific nucleases (SSNs) are crucial for precision mutagenesis and gene targeting in plants.
  • The DNA-binding activity of SSNs, independent of nuclease function, can recruit other protein domains to specific genomic loci.
  • CRISPR/Cas systems, when fused with epigenetic effectors, enable targeted epigenomic modifications in plants.

Purpose of the Study:

  • To review epigenetic modifications controlling agronomic traits in plants.
  • To examine epigenetic catalytic effectors in plants, including DNA methylases and histone modifiers.
  • To discuss strategies for functionalizing Cas proteins with epigenetic effectors and their impact on gene expression.

Main Methods:

  • Review of literature on epigenetic control of agronomic traits.
  • Analysis of plant epigenetic catalytic effectors (DNA methylases/demethylases, histone acetylases/deacetylases).
  • Examination of strategies for functionalizing CRISPR/Cas systems with epigenetic effector domains.

Main Results:

  • Epigenetic editing tools, particularly CRISPR/Cas-based systems, offer programmable targeted epigenomic modifications in plants.
  • Functionalized Cas proteins can influence endogenous gene expression in a regulatable manner.
  • Various epigenetic modifiers and their associated marks are well-studied in plants.

Conclusions:

  • Epigenetic editing holds significant potential for advancing plant biotechnology.
  • Targeted epigenomic modifications can be leveraged for crop improvement and breeding.
  • The ability to precisely alter plant epigenomes opens new avenues for trait development.