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Related Concept Videos

Chronic Obstructive Pulmonary Disease01:22

Chronic Obstructive Pulmonary Disease

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COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
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Chronic Obstructive Pulmonary Disease-I: Introduction01:20

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Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
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Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies01:27

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Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
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Pneumonia II: Pathophysiology01:29

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Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.01:25

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Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
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Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
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Updated: Nov 8, 2025

Machine Learning-Based Cough Tone Classification: Diagnostic Exploration of Chronic Obstructive Pulmonary Disease and Respiratory Tract Infections
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[Cough - an Interdisciplinary Condition: The Pneumologist's Perspective].

Nikolay Pavlov1, Verena Seif1, Gunar Günther1

  • 1Universitätsklinik für Pneumologie, Inselspital, Universitätsspital Bern.

Therapeutische Umschau. Revue Therapeutique
|April 26, 2021
PubMed
Summary
This summary is machine-generated.

Cough is a common medical issue, often caused by infections or chronic conditions like asthma. New treatments targeting specific cough mechanisms show promise for chronic cough cases.

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Area of Science:

  • Pulmonology
  • Internal Medicine

Background:

  • Cough is a frequent reason for medical consultation, with acute and subacute coughs typically linked to infections.
  • Chronic cough is often associated with obstructive airway diseases, gastroesophageal reflux, or upper airway cough syndrome.

Purpose of the Study:

  • To provide a pneumologist's perspective on the diagnosis and management of cough.
  • To review current and emerging treatments for various types of cough.

Main Methods:

  • Diagnostic workup includes spirometry, bodyplethysmography, blood eosinophil count, exhaled nitric oxide, methacholine challenge tests, chest X-rays, and CT scans.
  • Treatment strategies focus on addressing underlying causes, with inhaled corticosteroids considered for suspected asthma.

Main Results:

  • Gefapixant, a P2X3 receptor antagonist, shows positive results in clinical trials for chronic refractory and idiopathic cough.
  • The development of specific cough-modulating substances may offer new therapeutic options.

Conclusions:

  • Effective cough management requires identifying and treating the underlying cause.
  • Emerging therapies like Gefapixant represent a significant advancement in treating refractory chronic cough.