Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Community Based Intervention

Community Based Intervention

Community-based interventions in mental health represent a paradigm shift from institution-centered care to treatments embedded within the fabric of local communities. By prioritizing inclusion and leveraging existing societal structures, this approach fosters a supportive environment conducive to addressing mental health challenges while promoting individual dignity and agency.
Foundations of Community Mental Health Programs
Central to the success of community-based interventions is the...

Microenvironments

Microenvironments

Microorganisms inhabit highly localized spaces known as microenvironments, which are defined by distinct physical and chemical characteristics. These include oxygen concentration, pH, temperature, light availability, and nutrient levels. The conditions within a microenvironment can differ markedly from those in the surrounding area and significantly influence microbial growth, metabolism, and community structure.Microenvironments often display sharp physicochemical gradients over small spatial...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Complement-ARIE: Catalyzing the Development and Adoption of New Approach Methodologies.

NAM journal·2025

Same author

Taking the 3Rs to a higher level: replacement and reduction of animal testing in life sciences in space research.

Biotechnology advances·2025

Same author

Biology-inspired dynamic microphysiological system approaches to revolutionize basic research, healthcare and animal welfare.

ALTEX·2025

Same author

Extracellular RNA communication: A decade of NIH common fund support illuminates exRNA biology.

Journal of extracellular vesicles·2025

Same author

Leveraging biomarkers and translational medicine for preclinical safety - Lessons for advancing the validation of alternatives to animal testing.

ALTEX·2024

Same author

Engineering multicellular living systems-a Keystone Symposia report.

Annals of the New York Academy of Sciences·2022

Search research articles

Related Experiment Video

Updated: Jun 27, 2026

Methodology for Establishing a Community-Wide Life Laboratory for Capturing Unobtrusive and Continuous Remote Activity and Health Data

Methodology for Establishing a Community-Wide Life Laboratory for Capturing Unobtrusive and Continuous Remote Activity and Health Data

Published on: July 27, 2018

Microphysiological systems: What it takes for community adoption.

Passley Hargrove-Grimes¹, Lucie A Low¹, Danilo A Tagle¹

¹390834National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD 20892, USA.

Experimental Biology and Medicine (Maywood, N.J.)

|April 26, 2021

Summary

This summary is machine-generated.

Microphysiological systems (MPS) offer improved drug development for rare and neural diseases. Overcoming challenges in device creation, validation, and commercialization is key to their wider adoption.

Keywords:

Microphysiological systems National Institutes of Health bioengineering induced pluripotent stem cells microfluidics

More Related Videos

Author Spotlight: Developing a Unique Modular Microphysiological System to Mimic Human Barrier Tissue

Author Spotlight: Developing a Unique Modular Microphysiological System to Mimic Human Barrier Tissue

Published on: February 16, 2024

Updated Protocol for the Assembly and Use of the Minibioreactor Array (MBRA)

Updated Protocol for the Assembly and Use of the Minibioreactor Array (MBRA)

Published on: September 5, 2025

Related Experiment Videos

Last Updated: Jun 27, 2026

Methodology for Establishing a Community-Wide Life Laboratory for Capturing Unobtrusive and Continuous Remote Activity and Health Data

Methodology for Establishing a Community-Wide Life Laboratory for Capturing Unobtrusive and Continuous Remote Activity and Health Data

Published on: July 27, 2018

Author Spotlight: Developing a Unique Modular Microphysiological System to Mimic Human Barrier Tissue

Author Spotlight: Developing a Unique Modular Microphysiological System to Mimic Human Barrier Tissue

Published on: February 16, 2024

Updated Protocol for the Assembly and Use of the Minibioreactor Array (MBRA)

Updated Protocol for the Assembly and Use of the Minibioreactor Array (MBRA)

Published on: September 5, 2025

Area of Science:

Biotechnology
Drug Development
In Vitro Models

Background:

Microphysiological systems (MPS) show promise for enhancing drug development, especially for rare diseases, neural disorders, and pediatric conditions.
The National Center for Advancing Translational Sciences (NCATS) aims to demonstrate the utility and support the adoption of MPS technology.

Purpose of the Study:

To identify current barriers hindering the community adoption of microphysiological systems.
To provide an outlook on the future adoption pathway for these in vitro tools from an NCATS perspective.

Main Methods:

This Minireview presents a perspective from the NCATS on the adoption of MPS.
Analysis of existing challenges in MPS technology and its integration into research and development.

Main Results:

Adoption of MPS is impeded by biological and technological challenges in device development.
Issues with validation, standardization, and commercialization also hinder widespread use of MPS.

Conclusions:

Addressing the identified barriers is crucial for the successful integration and community adoption of MPS.
Future strategies are needed to facilitate the path towards widespread use of these advanced in vitro tools.