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Total Synthesis of the Proposed Structure of Characellide B
Yong Wang1, Zhenwei Wang1, Zhe Wang1
1State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing Key Laboratory of Active Substances Discovery and Druggability Evaluation, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Abstract:
We achieved the total synthesis of the proposed structure of characellide B, a novel lipoglycotripeptide. Comparison of the data for the synthetic compound with those for the natural product indicated some possible errors in the original structural assignment. Furthermore, we synthesized the other four stereoisomers, focusing on the d-Asp-d-allo-Thr fragment, to determine the actual structure of characellide B. Nevertheless, the data for the stereoisomers were not consistent with those for the natural product.
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