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Total Synthesis of Brasilicardin A

Zhe Wang1, Yuan Wang1, Danyang Hu1

  • 1State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing Key Laboratory of Active Substances Discovery and Druggability Evaluation, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.

The Journal of Organic Chemistry
|December 26, 2025
PubMed
Summary

Researchers developed a new synthesis for brasilicardin A, a potent immunosuppressant. This practical method efficiently creates its complex trans-syn-trans perhydrophenanthrene core structure.

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