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Updated: Nov 7, 2025
A 3D Organotypic Melanoma Spheroid Skin Model
Published on: May 18, 2018
Primary malignant mucosal melanoma of the maxillofacial area
Hyounmin Kim1, Sanghoon Lee2, In-Ho Cha1
1Department of Oral and Maxillofacial Surgery, Yonsei University College of Dentistry, Seoul, Korea.
Objectives:
We aimed to collect and report data from all patients who have been diagnosed with mucosal malignant melanoma to obtain the epidemiology and principles of current treatments.
Materials And Methods:
Between January 2008 and December 2018, 20 patients underwent surgery or follow-up observations at Yonsei University Dental Hospital. The patients' clinical information was reviewed retrospectively.
Results:
Seventeen of 20 patients had undergone definitive surgery, while only 6 patients received adjuvant radiotherapy or systemic therapy. Eight of 20 patients, including those that had recurrent lesions, were provided immunotherapy. The 3-year survival for all stages was 50%, with a local recurrence rate of 75% and a metastasis rate of 65%.
Conclusion:
The overall survival of patients receiving surgical treatment was longer than that of patients who did not undergo surgical resection. Eight of 20 patients received immunotherapy as the first-line regimen at our clinic, and those patients exhibited longer overall survival compared to patients in reported keynote studies.
