Evaluation of the Association between Paranasal Sinus Osteomas and Anatomic Variations Using Computed Tomography

Area of Science:

• Radiology
• Otolaryngology
• Pathology

Background:

• The exact cause of paranasal sinus osteomas (PSOs) is not fully understood, with embryological and developmental factors suspected.
• Investigating the relationship between PSO occurrence, location, and anatomical variations is crucial for understanding its pathogenesis.

Purpose of the Study:

• To determine the frequency and common locations of PSOs using computed tomography (CT).
• To explore the association between paranasal sinus anatomical variations and the presence of PSOs.

Main Methods:

• A retrospective review of 18,867 paranasal sinus, maxillofacial CT, and brain CT angiography scans was performed.
• Patient data, including PSO size and accompanying mucosal pathologies, were analyzed.
• Statistical comparisons were made between patients with PSOs and a control group (200 patients without PSO).

Main Results:

• Paranasal sinus osteomas (PSOs) were identified in 176 patients (0.92%), with a mean age of 59.9 years.
• The frontal sinuses were the most common location for PSOs; they were unilateral in most cases.
• Significantly higher frequencies of several anatomical variations, including Haller's cell and frontal sinus hypoplasia, were observed in patients with PSOs compared to controls.

Conclusions:

• The observed differences in anatomical variations suggest potential genetic and/or environmental influences on PSO development.
• Further research is warranted to elucidate the complex associations between anatomical variations and PSO etiology.