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Nephrotoxicity of Anti-Angiogenic Therapies

Margaux Van Wynsberghe1, Joanne Flejeo1,2, Hamza Sakhi1

  • 1INSERM, Institut Mondor de Recherche Biomédicale, Paris Est Creteil University, F-94010 Creteil, France.

Diagnostics (Basel, Switzerland)
|April 30, 2021
PubMed

Insights

Anti-angiogenic therapies targeting vascular endothelial growth factor (VEGF) improve cancer outcomes but can cause kidney damage. This review details VEGF/VEGFR2 inhibitor nephrotoxicity, its mechanisms, and resulting renal diseases.

Area of Science:

  • Oncology
  • Nephrology
  • Molecular Biology

Background:

  • Vascular Endothelial Growth Factor (VEGF) signaling is crucial for angiogenesis and kidney function.
  • Anti-angiogenic therapies targeting VEGF/VEGFR2 are increasingly used in cancer treatment.
  • These therapies can cause significant adverse nephrotoxic effects.

Purpose of the Study:

  • To review anti-angiogenic therapies targeting the VEGF pathway.
  • To examine the incidence of renal manifestations associated with these therapies.
  • To discuss the pathophysiological mechanisms of VEGF inhibitor-induced nephrotoxicity.

Main Methods:

  • Literature review of anti-angiogenic therapies and their renal side effects.
  • Analysis of pathophysiological mechanisms of kidney diseases linked to VEGF inhibition.
  • Compilation of data on cellular damage from these treatments.

Main Results:

  • VEGF/VEGFR2 inhibitors are associated with various renal complications.
  • Common renal manifestations include hypertension, proteinuria, renal dysfunction, and electrolyte imbalances.
  • Specific cellular damage patterns are observed following these therapies.

Conclusions:

  • Anti-angiogenic therapies targeting VEGF/VEGFR2, while beneficial in oncology, pose a risk of significant kidney damage.
  • Understanding the mechanisms of nephrotoxicity is crucial for patient management.
  • Further research is needed to mitigate renal side effects of these vital cancer treatments.
Keywords:
VEGF signalingkidneytoxicity

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