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[Anti-cytoplasmic antibodies in the diagnosis of vasculitis]

B Nölle1, W L Gross

  • 1Abteilung Allgemeine Innere Medizin, Universität, Kiel.

Immunitat Und Infektion
|April 1, 1988
PubMed

Insights

Antibodies against cytoplasmic structures of neutrophilic granulocytes and monocytes (ACPA) are highly specific for diagnosing Wegener's granulomatosis. ACPA testing identified WG in 77/105 patients, with only 8/123 other vasculitis patients testing positive.

Area of Science:

  • Immunology
  • Rheumatology
  • Pathology

Context:

  • Wegener's granulomatosis (WG) is a systemic vasculitis.
  • Accurate diagnostic markers for WG are crucial.

Purpose:

  • To evaluate the diagnostic specificity of antibodies against cytoplasmic structures of neutrophilic granulocytes and monocytes (ACPA) for Wegener's granulomatosis.

Summary:

  • Antibodies against cytoplasmic structures of neutrophilic granulocytes and monocytes (ACPA) were detected in 77 out of 105 patients with clinically and histologically confirmed WG.
  • Only 8 out of 123 patients with other forms of vasculitis tested positive for ACPA, including 3 with panarteritis nodosa and 5 with unclassified systemic vasculitides.
  • Elevated C-reactive protein (CRP) levels, indicating systemic inflammation, were observed in approximately half of the ACPA-positive WG patients.

Impact:

  • ACPA testing demonstrates high specificity for Wegener's granulomatosis diagnosis.
  • This finding can aid in differentiating WG from other vasculitic conditions.
  • Supports the utility of ACPA as a valuable serological marker in rheumatological diagnostics.

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