Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

CRISPR/Cas9-Mediated Gene Knockout Reveals a Nonredundant Role for p16<sup>INK4A</sup> in Controlling TCR-Dependent and Independent CD8 T Cell Expansion.

European journal of immunology·2026
Same author

Sustainable AFM-Based Nanolithography on Chitosan Thin Films for 2.5D and 3D Nanostructure Fabrication.

Nanomaterials (Basel, Switzerland)·2026
Same author

Chitosan Nanoparticles Unlock the Antioxidant Potential of Epigallocatechin Gallate in Pancreatic and Hepatic Cancer Cell Models.

ACS omega·2026
Same author

Molecular imprinting for neurology: Materials, applications, and limitations.

Ibrain·2026
Same author

A critical guideline for controlling monocyte-derived macrophages phenotypes.

Frontiers in immunology·2026
Same author

Autosomal Dominant Hyper-IgE Syndrome Patients Retain IL10-Producing preTh17-Cells That Are Activated by Opportunistic Pathogens and Support IgE Production.

Allergy·2026

Related Experiment Video

Updated: Nov 7, 2025

Systematic Approach to Identify Novel Antimicrobial and Antibiofilm Molecules from Plants' Extracts and Fractions to Prevent Dental Caries
08:20

Systematic Approach to Identify Novel Antimicrobial and Antibiofilm Molecules from Plants' Extracts and Fractions to Prevent Dental Caries

Published on: March 31, 2021

6.6K

Engineering Polymeric Nanosystems against Oral Diseases.

Valeria Mercadante1, Edoardo Scarpa2,3, Valeria De Matteis4

  • 1Division of Oral Medicine, UCL Eastman Dental Institute, Bloomsbury Campus, Rockefeller Building, 21 University Street, London WC1E 6DE, UK.

Molecules (Basel, Switzerland)
|April 30, 2021
PubMed
Summary

This review explores polymeric nanoparticles for oral diseases, highlighting production optimization, preclinical assessment, and scale-up for clinical translation of these advanced healthcare therapeutics.

Keywords:
cariesclinical studiesendodontologynanotechnologyoral canceroral diseasesoral medicineperiodontologypolymeric nanoparticlespre-clinical modelsrestorative dentistry

More Related Videos

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
14:20

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Published on: June 13, 2014

16.9K
Advanced Compositional Analysis of Nanoparticle-polymer Composites Using Direct Fluorescence Imaging
07:41

Advanced Compositional Analysis of Nanoparticle-polymer Composites Using Direct Fluorescence Imaging

Published on: July 19, 2016

7.9K

Related Experiment Videos

Last Updated: Nov 7, 2025

Systematic Approach to Identify Novel Antimicrobial and Antibiofilm Molecules from Plants' Extracts and Fractions to Prevent Dental Caries
08:20

Systematic Approach to Identify Novel Antimicrobial and Antibiofilm Molecules from Plants' Extracts and Fractions to Prevent Dental Caries

Published on: March 31, 2021

6.6K
Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
14:20

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Published on: June 13, 2014

16.9K
Advanced Compositional Analysis of Nanoparticle-polymer Composites Using Direct Fluorescence Imaging
07:41

Advanced Compositional Analysis of Nanoparticle-polymer Composites Using Direct Fluorescence Imaging

Published on: July 19, 2016

7.9K

Area of Science:

  • Nanomedicine
  • Biomaterials Science
  • Oral Health Research

Background:

  • Nanoparticles (NPs) are pivotal in healthcare, with polymeric NPs showing significant therapeutic potential.
  • Oral diseases present a substantial burden, necessitating innovative treatment strategies.
  • Translating laboratory advancements in polymeric NPs to clinical use requires careful consideration of production and application.

Purpose of the Study:

  • To review the critical factors for optimizing polymeric NP production for oral disease therapeutics.
  • To contextualize the application of polymeric NPs against prevalent oral diseases using recent literature.
  • To discuss the necessary steps for clinical translation, including preclinical assessment and scale-up.

Main Methods:

  • Literature review focusing on polymeric NP synthesis and characterization for therapeutic applications.
  • Analysis of studies addressing biocompatibility, biodistribution, and biodegradability of polymeric NPs.
  • Examination of preclinical models (in vitro, ex vivo, in vivo) for evaluating NP efficacy and safety.
  • Review of scale-up considerations and clinical trial pathways for NP-based therapies.

Main Results:

  • Polymeric NPs offer tunable properties for targeted drug delivery in oral conditions.
  • Biocompatibility, biodistribution, and biodegradability are key parameters influencing NP performance and safety.
  • Preclinical models are essential for validating the efficacy and safety of NPs before clinical trials.
  • Successful clinical translation hinges on robust scale-up strategies and a clear regulatory pathway.

Conclusions:

  • Optimized polymeric NPs demonstrate significant promise for treating various oral diseases.
  • Addressing production, safety, efficacy, and scalability is crucial for successful clinical implementation.
  • Further research and development are needed to fully realize the potential of polymeric NPs in oral healthcare.