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CLL/SLL specifically binding to the APC fluorochrome: A previously undescribed phenomenon

Wesley Smith1, Alexa Rodriguez2, Chelsea-Ann Patry2

  • 1Department of Internal Medicine, Prisma Health Upstate, Greenville, South Carolina, United States.

Cytometry. Part B, Clinical Cytometry
|April 30, 2021
PubMed
Abstract

No abstract available in PubMed .

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The stepwise destruction of specific proteins is necessary for the progression and completion of the cell cycle. Such proteins are ubiquitinated by ubiquitin ligases and then subsequently destroyed by the proteasome. The SCF (Skp1/Cullin/F-box) and the anaphase-promoting complex (APC) are two important ubiquitin ligases involved in cell cycle progression. While SCF is active throughout the cell cycle, APC gets activated during metaphase to anaphase transition. Cdc20 or Cdh1 binds to APC and...