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Recombinant basic fibroblast growth factor accelerates wound healing.

G S McGee1, J M Davidson, A Buckley

  • 1Department of Surgery, Vanderbilt University School of Medicine, Nashville, Tennessee 37232.

The Journal of Surgical Research
|July 1, 1988
PubMed
Summary
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Basic fibroblast growth factor (bFGF) significantly accelerates wound healing in rats. Treated wounds showed increased tensile strength and breaking energy, suggesting enhanced collagen accumulation and organization.

Area of Science:

  • Regenerative Medicine
  • Wound Healing Research
  • Biomedical Engineering

Background:

  • Basic fibroblast growth factor (bFGF) is known to stimulate extracellular matrix metabolism and cell growth.
  • Previous studies indicated bFGF increases collagen content in artificial matrices.
  • This research investigates bFGF's effect on incisional wound healing in a live animal model.

Purpose of the Study:

  • To determine if basic fibroblast growth factor (bFGF) accelerates the healing of incisional wounds.
  • To evaluate the impact of bFGF on wound tensile strength, breaking energy, and collagen content.
  • To assess the histological changes in bFGF-treated wounds.

Main Methods:

  • Male Sprague-Dawley rats underwent dorsal incisions, with one incision per pair receiving bFGF injection on Day 3.

Related Experiment Videos

  • Wound tensile strength and breaking energy were measured using a tensiometer on Days 5, 6, and 7.
  • Wound collagen content was quantified via hydroxyproline measurement using high-performance liquid chromatography.

    • Main Results:

    • bFGF treatment led to a significant increase in fresh wound tensile strength (P < 0.01) and breaking energy (P < 0.001).
    • A non-significant increase in wound collagen content was observed.
    • Histological examination revealed better organization and maturation of bFGF-treated wounds compared to controls.

    Conclusions:

    • Recombinant bFGF effectively accelerates normal rat wound healing.
    • The accelerated healing may be attributed to earlier collagen and fibroblast accumulation or increased collagen crosslinking.
    • bFGF shows potential as a therapeutic agent for enhancing wound repair.