Utilizing neutron generators in boron neutron capture therapy

Area of Science:

• Medical Physics
• Nuclear Engineering
• Radiotherapy

Background:

• Neutron capture therapy (NCT) uses neutron capture reactions to damage tumor cells.
• Nuclear reactors are the conventional source for NCT due to high neutron fluence rates.
• Limited research exists on the efficacy of neutron generators for NCT.

Purpose of the Study:

• To present preliminary simulation results of using a deuterium-deuterium (D-D) generator for boron neutron capture therapy (BNCT).
• To evaluate the feasibility of D-D generators as an alternative neutron source for BNCT.

Main Methods:

• Utilized MCNP 6.1 software for detailed modeling of the D-D neutron generator and phantom.
• Incorporated neutron moderators to optimize neutron fluence rate in the tumor.
• Implemented photon shielding to minimize dose to surrounding healthy tissues.

Main Results:

• Achieved good localization of neutron dose within the targeted tumor area.
• Demonstrated a significant reduction in photon dose to surrounding tissues.
• Preliminary simulations indicate potential for effective dose delivery in BNCT.

Conclusions:

• Deuterium-deuterium generators show promise as a viable neutron source for BNCT.
• Optimization of neutron moderators and photon shielding is crucial for effective treatment.
• Further research is warranted to validate these simulation findings experimentally.