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Bacterial Flora of the Large Intestine01:29

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The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
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Related Experiment Video

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Author Spotlight: Advancing Intestinal Bacteria Cultivation for Poultry
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Baicalin-Aluminum Modulates the Broiler Gut Microbiome.

Ling Guo1,2, Jing He1,2, Jiacheng Zhang1,2

  • 1Hubei Key Laboratory of Animal Nutrition and Feed Science, Wuhan Polytechnic University, Wuhan, P.R. China.

DNA and Cell Biology
|May 4, 2021
PubMed
Summary

Baicalin-aluminum significantly altered the gut microbiome in broilers, increasing beneficial bacteria like Lactobacillus. This suggests baicalin-aluminum could be a novel therapy for gut health in animals and humans.

Keywords:
baicalin-aluminumbroilerscolistin sulfategut microbiome

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Area of Science:

  • Microbiology
  • Animal Science
  • Pharmacology

Background:

  • Baicalin-aluminum is known to regulate the gut microbiome in piglets.
  • Its effects on poultry gut microbiome composition and function are not well understood.

Purpose of the Study:

  • To investigate the impact of baicalin-aluminum on the gut microbiome of poultry.
  • To compare these effects with colistin sulfate administration.

Main Methods:

  • Metagenomic sequencing was employed to analyze gut microbiome changes in broilers.
  • Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses were performed.

Main Results:

  • Baicalin-aluminum administration led to significant alterations in broiler gut microbiome composition, with notable increases in species such as *Lactobacillus salivarius* and *Bacteroides uniformis* compared to colistin.
  • Functional analysis revealed enrichment in metabolic processes, catalytic activity, cellular processes, ABC transporters, oxidative phosphorylation, and phosphotransferase systems.

Conclusions:

  • Baicalin-aluminum effectively modifies the gut microbiome composition in broilers.
  • These findings provide insights into baicalin-aluminum's functions and suggest its potential as a therapeutic agent for gut health.