[Corrigendum] Cyclophilin D modulates cell death transition from early apoptosis to programmed necrosis induced by
Wei Tian1, Dong Xu1, Weidong Han2
1Department of Surgical Oncology, The Second Affiliated Hospital, School of Medicine,Zhejiang University, Hangzhou 310009, P.R. China.
Insights
This corrigendum addresses errors in Figure 6, specifically the BCL-xl bands, which were mistakenly compiled from the GAPDH dataset. Re-experimentation confirmed the original study
Area of Science:
- Molecular Biology
- Cellular Signaling
- Cancer Research
Context:
- The original article investigated cellular signaling pathways relevant to cancer.
- Figure 6 presented critical western blot data supporting the study's conclusions.
- An anomaly was identified concerning the data presented in Figure 6.
Purpose:
- To correct erroneous data in Figure 6 related to BCL-xl protein bands.
- To address potential data duplication issues within Figure 6 and between Figures 5 and 6.
- To provide a revised figure with accurate data and reaffirm the study's findings.
Summary:
- Errors in the original Figure 6 involved the incorrect selection of BCL-xl bands from the GAPDH dataset.
- Original western blot images were unavailable; therefore, experiments were repeated to corroborate results.
- Revised Figure 6, containing newly generated data, is presented, confirming the original study's conclusions.
Impact:
- Ensures the accuracy and integrity of the published scientific record.
- Reaffirms the validity of the study's conclusions despite the data compilation error.
- Provides corrected data for researchers utilizing or referencing this study in cancer research.
Abstract:
Subsequently to the publication of the above article, the authors have realized that the printed version of Fig. 6 on p. 1661 contained some mistakes. Potential anomalies regarding this figure concerning the duplication of data both within Fig. 6 and comparing data between Figs. 5 and 6 were also drawn to our attention by an interested reader. Specifically, the authors realized that the bands of BCL‑xl were erroneously selected from the GAPDH dataset during the process of compiling this figure. The authors subsequently found that the original photographs of these western blot bands had been lost during the time period that had elapsed since these experiments were completed. In order to corroborate the results, the authors repeated the contentious experiments shown in Fig. 6 and obtained similar results, thereby corroborating the results and conclusions reported in this study. A revised version of Fig. 6, containing the newly obtained data, is shown below. The errors made with the assembly of Fig. 6 originally did not have an adverse bearing on the overall conclusions reported in this study. The authors are grateful to the Editor of International Journal of Oncology for allowing them the opportunity to publish this Corrigendum, and all of the authors agree to the publication of this Corrigendum. The authors sincerely apologize for their errors, and apologize to the readership of the Journal for any inconvenience caused. [the original article was published in International Journal of Oncology 42: 1654‑1663, 2013; DOI: 10.3892/ijo.2013.1863].
Related Concept Videos
The Intrinsic Apoptotic Pathway
The Extrinsic Apoptotic Pathway
Overview of Cell Death
Cell death was observed in the early 19th century, but there was no experimental evidence to prove it. In 1842, Carl Vogt first discovered cell death in a metamorphic toad; however, it was not termed ‘cell death.’ Scientists discovered different cell death pathways only in the...
Autophagic Cell Death
Autophagy and Apoptosis
Autophagy can activate apoptosis. In normal conditions, the autophagy activating protein Beclin-1 and...
Apoptosis
Phagocytosis of Apoptotic Cells
Normal cells contain receptors that prevent them from being recognized...


