Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

1.0K
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
1.0K
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

788
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
788
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

919
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
919

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Metabolomic signatures and causal effects of circulating metabolites on age-related cataract.

The journals of gerontology. Series A, Biological sciences and medical sciences·2026
Same author

Can the two-point method based on peak and trough concentrations accurately estimate the area under the curve of polymyxin B? A Monte Carlo simulation study.

Frontiers in pharmacology·2026
Same author

Comparative efficacy and safety of extended versus continuous infusion of beta-lactam antibiotics for severe infection: a network meta-analysis of randomized trials.

Critical care (London, England)·2026
Same author

Intrinsic Capacity, Polygenic Risk Score, and Risk of Glaucoma.

Translational vision science & technology·2026
Same author

CITF1 fine-tunes FIT activity to regulate Fe uptake.

The Plant cell·2026
Same author

Identifying potential therapeutic targets for high myopia via a case-control study and Mendelian randomisation analyses of the human blood metabolome.

Eye (London, England)·2026

Related Experiment Video

Updated: Nov 6, 2025

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis
13:47

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis

Published on: June 3, 2018

9.5K

Metabolomics in Glaucoma: A Systematic Review.

Ying Wang1, Xiao-Wen Hou1, Gang Liang2,3

  • 1School of Public Health, Medical College of Soochow University, Suzhou, China.

Investigative Ophthalmology & Visual Science
|May 6, 2021
PubMed
Summary

This review identifies key metabolites linked to open-angle glaucoma (OAG), highlighting amino acid metabolism alterations. Further research is needed to confirm these glaucoma biomarkers and explore their presence across different biological samples.

More Related Videos

A Magnetic Microbead Occlusion Model to Induce Ocular Hypertension-Dependent Glaucoma in Mice
09:26

A Magnetic Microbead Occlusion Model to Induce Ocular Hypertension-Dependent Glaucoma in Mice

Published on: March 23, 2016

20.0K
Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation
08:30

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation

Published on: March 12, 2016

13.3K

Related Experiment Videos

Last Updated: Nov 6, 2025

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis
13:47

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis

Published on: June 3, 2018

9.5K
A Magnetic Microbead Occlusion Model to Induce Ocular Hypertension-Dependent Glaucoma in Mice
09:26

A Magnetic Microbead Occlusion Model to Induce Ocular Hypertension-Dependent Glaucoma in Mice

Published on: March 23, 2016

20.0K
Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation
08:30

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation

Published on: March 12, 2016

13.3K

Area of Science:

  • Metabolomics
  • Biomarker Discovery
  • Ophthalmology

Background:

  • Glaucoma is a complex optic neuropathy with poorly understood mechanisms.
  • Early diagnosis through reliable biomarkers is crucial for preventing vision loss.
  • Metabolomics offers a promising approach to identify glaucoma-related metabolic signatures.

Purpose of the Study:

  • To systematically review and analyze current metabolomic studies on glaucoma.
  • To identify and summarize reported metabolites associated with glaucoma.
  • To provide insights into the metabolic profiles and pathophysiology of glaucoma.

Main Methods:

  • Comprehensive literature search of PubMed and Web of Science databases.
  • Inclusion of metabolomics studies (mass spectrometry or NMR-based) on human glaucoma.
  • Pathway and topology analyses using MetaboAnalyst 3.0 for metabolic signature generation.

Main Results:

  • 18 articles were reviewed, with 13 focusing on open-angle glaucoma (OAG).
  • Seventeen metabolites, including amino acids, phosphatidylcholines, and acylcarnitines, were repeatedly identified in OAG.
  • Pathway analysis indicated a significant role of amino acid metabolism in OAG.

Conclusions:

  • Metabolomic studies reveal metabolic disorders in OAG patients, offering insights into disease mechanisms.
  • Identified metabolites serve as potential biomarkers for glaucoma diagnosis.
  • Further research is required to validate findings and investigate metabolite patterns across biological fluids.