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Orthobiologics in Hand Surgery.

Kristin E Karim1, Caroline M Wu1, Aviram M Giladi1

  • 1Curtis National Hand Center, MedStar Union Memorial Hospital, Baltimore, MD.

The Journal of Hand Surgery
|May 7, 2021
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Summary

Orthobiologic agents show promise for upper-extremity conditions like carpal tunnel syndrome. However, more research is needed to confirm their effectiveness, especially for hand and wrist injuries.

Keywords:
Arthritiscarpal tunnel syndromeorthobiologic agentplatelet-rich plasmatendon rupture

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Area of Science:

  • Orthopedics
  • Regenerative Medicine

Background:

  • Orthobiologic agents are increasingly used as adjuvant therapies for upper-extremity conditions.
  • Commonly treated conditions include carpal tunnel syndrome, de Quervain tenosynovitis, and distal radius fractures.

Purpose of the Study:

  • To conduct a narrative review of current literature on orthobiologic agents in the upper extremity.
  • To evaluate the evidence for various orthobiologics in treating hand and wrist pathologies.

Main Methods:

  • A narrative review of existing literature was performed.
  • Studies included randomized control trials, case studies, and animal studies.
  • Orthobiologics evaluated: bone morphogenetic proteins, platelet-rich plasma, bone marrow aspirate concentrate, mesenchymal stem cells, and amniotic membrane.

Main Results:

  • Some clinical evidence supports orthobiologics for shoulder, elbow, and sports injuries.
  • There is a limited amount of literature on their use for hand and wrist pathologies.
  • The effectiveness of these agents for specific hand and wrist conditions remains largely unproven.

Conclusions:

  • Orthobiologics represent an innovative approach to upper-extremity treatment.
  • Further investigation is crucial to establish the efficacy and therapeutic value of orthobiologics for hand and wrist injuries.
  • More research is needed to fully understand their role in treating upper extremity pathology.