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REV7: Jack of many trades
Inge de Krijger1, Vera Boersma1, Jacqueline J L Jacobs1
1Division of Oncogenomics, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands.
Trends in Cell Biology
|May 8, 2021
Summary
REV7 protein is crucial for maintaining genome integrity through its roles in DNA repair and cell division. Its versatile structure enables participation in various protein complexes, impacting diverse cellular processes.
Area of Science:
- Molecular Biology
- Cell Biology
- Genetics
Background:
- REV7 (MAD2L2) is a HORMA domain protein involved in multiple cellular processes.
- Its interactions with various proteins form complexes that influence cellular functions.
- REV7's roles in DNA repair and cell division are increasingly recognized.
Purpose of the Study:
- To discuss the diverse roles of REV7 in various protein complexes.
- To highlight REV7's function in maintaining genome integrity.
- To describe the structural features contributing to REV7's versatility.
Main Methods:
- Literature review and synthesis of existing research on REV7.
- Analysis of REV7's interactions and complex formations.
- Examination of structural data related to REV7.
Main Results:
- REV7 participates in translesion synthesis and mitotic progression.
- REV7 is a key component of the shieldin complex, essential for DNA double-strand break repair.
- REV7's structural characteristics underpin its ability to engage in diverse molecular interactions.
Conclusions:
- REV7 is a versatile protein critical for genome stability.
- Understanding REV7's structure-function relationship is key to its diverse cellular roles.
- REV7's involvement in DNA repair and cell cycle regulation underscores its importance in maintaining genomic integrity.
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